Glyceraldehyde-3-phosphate dehydrogenase or GAPDH is an important enzyme of the glycolytic pathway. It is an NADH-dependent enzyme that catalyzes the sixth step of the glycolytic pathway during which it converts the glyceraldehyde-3-phosphate (G3P) to 1,3-diphosphoglycerate. However, a recent study shows that it has not only catalytic role …
Mitochondrial storage of the excess of Zn and Ca ions Zinc and calcium ions play important roles in maintaining the mitochondrial redox state. Membrane-associated enzymes constituting an electron transport chain are embedded in the inner membrane of the mitochondria. They perform the electron transport during which the …
Colon Cancer Researchers have made different investigations to understand the mechanism of tumorigenesis in gastrointestinal cancers. They found that overexpression of the cyclin D2 and CDK4/6 and loss of function of the APC in the intestinal epithelial cancer, suggesting that deregulation of the CDK4/6 is required …
Cyclin-dependent protein kinase plays an important role in cell cycle regulation. The decision of a cell to divide or not is crucially important to the organism. When the cell division regulatory mechanism is defective and cells undergo unregulated division, then it results in catastrophic cancer such …
Regulation of the Glycolytic Pathway There is a total of ten enzymes in the glycolytic pathway but not all the enzymes are involved in the regulation, but only three of them are important for the point of regulation of the glycolytic pathway. These enzymes are mostly regulated by …
