Tag: Cyclin Dependent Protein Kinases

 Colon Cancer Researchers have made different investigations to understand the mechanism of tumorigenesis in gastrointestinal cancers. They found that overexpression of the cyclin D2 and CDK4/6 and loss of function of the APC in the intestinal epithelial cancer, suggesting that deregulation of the CDK4/6 is required …

 The proliferation of the gastrointestinal cancer is not only linked to the activation of the different types of oncogenes such as Ras proteins and dysfunction of the tumor suppressor genes but also linked to the DNA repair pathway and cell cycle deregulation. The cell cycle is …