Glyceraldehyde-3-phosphate dehydrogenase or GAPDH is an important enzyme of the glycolytic pathway. It is an NADH-dependent enzyme that catalyzes the sixth step of the glycolytic pathway during which it converts the glyceraldehyde-3-phosphate (G3P) to 1,3-diphosphoglycerate. However, a recent study shows that it has not only catalytic role …
Biochempages
Enzymes
December 23, 2015
Angiotensin II from Angiotensinogen Angiotensin is a group of peptide hormones that contains mainly four types; I, II, III, and IV. However, the biologically active form is angiotensin II. All of these are produced from the single precursor protein angiotensinogen in different steps. Angiotensinogen is a …
Regulation of the Glycolytic Pathway There is a total of ten enzymes in the glycolytic pathway but not all the enzymes are involved in the regulation, but only three of them are important for the point of regulation of the glycolytic pathway. These enzymes are mostly regulated by …
Intramembrane proteolysis is a degradation of proteins within the plane of a lipid bilayer membrane. It is a widespread phenomenon contributing to the functional activation of the substrates and it is also involved in several diseases. Many families of intramembrane proteases have been discovered and characterized, …
Mammalian thioredoxin reductase is a selenium-containing selenoenzyme. It contains selenocysteine instead of cysteine and selenium of selenocysteine acts as an electron acceptor during the catalysis. Selenium in the thioredoxin reductase is critical for catalysis because it has some important properties as it acts as a better …
A recent study has revealed that “Glutathione-S-Transferase P” can alleviate the Cyclophosphamide-induced cardiotoxicity. Cyclophosphamide (CY) is a chemical compound most commonly used to treat lymphoma, leukemia, and some other cancers. In fact, Cyclophosphamide is an anticancerous drug and it is also used as a preparatory treatment …
What is Glucose-6-Phosphate Dehydrogenase? Glucose-6-Phosphate Dehydrogenase is an NADP+ dependent enzyme that catalyzes the conversion of Glucose-6-Phosphate to 6-Phosphoglucono-∂-Lactone, the committed step of Pentose phosphate pathway. The pentose phosphate pathway has great importance in the production of NADPH and pentose sugars. It is mainly found in …
