PhD in posttranslational regulation of transcription dynamics

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(Last Updated On: April 21, 2017)
Ubiquitination as a way of posttranslational regulation of a protein

K63-Ubiquitination as a way of posttranslational regulation of a proteinĀ Images:Taraxacum via Common Wikimedia

A new position of Ph.D. in posttranslational regulation of transcriptional dynamics is available under the principle investigator Dr. Spoel from School of Biological Science, University of Edinburgh, UK. This is a funded project that involves the posttranslational regulation in plant immunity. This position is open for graduate students from biochemistry and related sciences. International students from any countries can apply for this post.


In eukaryotes, gene transcription is a dynamic process that changes over the cell development and cellular responses to the changing environments. Any failure or defect in gene transcription can lead to a serious problem for an organism and sometimes can lead to a disease or even death. Transcription of a gene is a highly regulated process. It is regulated by a series of transcriptional regulators the mechanism of which is poorly understood up to now.

Therefore, to investigate the mechanism of regulation of a gene transcription by transcriptional regulators, researchers are studying plant immune responses. The immune system in plants provides the new area of studies of the transcriptional regulator and their role in the activation of plant immunity associated with the transcription of the thousands of genes and their dynamics in the plant immune system.

Previously, the team of the researchers led by principal investigator De. Spoel has uncovered the posttranslational regulation through the modification of the transcriptional regulator and they found that these regulators play a crucial role in the regulation of the plant immune associated gene expression.

However, the activities of the transcriptional regulator are controlled by the redox reaction based modifications of the cysteine residues, disulfide bonds and some other processes including S-nitrosylation and ubiquitination of some proteasome-mediated protein degradations. These posttranslational modifications may regulate the activities of the transcriptional regulators by modifying their intracellular localization, their conformations and stabilities.

Therefore, selected Ph.D. candidates will have to use a wide range of fundamental principles such as genetics, transcriptomics, proteomics and biochemical strategies to uncover the specific posttranslational modifications that may affect the activity of plant immune-associated transcriptional regulators. That will also uncover the effect of these regulators on the disease resistance of the plant and may enable us to develop a novel approach of plant crop protection.

To apply or to know more about this position please visit this link.

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