Colorectal cancer is the third most common cancer that constitutes 50% of the total cancer-related death in the western world. People suffering from inflammatory bowel disorders like ulcerative colitis and Crohn’s diseases are more prone to colorectal cancer than others. ADVERTISEMENTS About 75% of the cases …
G-Protein Linked Cell Surface Receptors (GPCRs) GPCRs are the membrane proteins that constitute the largest superfamily of the protein. In the human genome, there are more than 800 G-protein linked cell surface receptors that are categorized into four superfamilies; Rhodopsin-like GPCRs, secretin-like/adhesion-like GPCRs, glutamate, and frizzled/Tas2 …
Intramembrane proteolysis is a degradation of proteins within the plane of a lipid bilayer membrane. It is a widespread phenomenon contributing to the functional activation of the substrates and it is also involved in several diseases. Many families of intramembrane proteases have been discovered and characterized, …
It has been found that cancerous cells follow metabolic remodeling to sustain cell growth and proliferation. Cancer cells require a large amount of energy as well as building blocks to synthesize new biomolecules like nucleic acids, proteins, and lipids required for cell proliferation and cofactors that …
According to a recent study, the N-terminal acetylation of the regulator glycoprotein and N-end rule degradation leads to hypertension. Blood pressure is regulated through the G-protein linked signaling pathway that causes vasoconstriction. Regulatory proteins such as Ras2 has been found to go through the N-terminal acetylation …
