Postdoctoral Position in Alternative Splicing and Diabetes

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(Last Updated On: April 23, 2017)
Alternative Splicing leading to the formation of two mature mRNA from a single primary mRNA transcript

Alternative Splicing leading to the formation of two mature mRNA from a single primary mRNA transcript. Image: Seru via Common Wikimedia

Are you looking for a postdoctoral fellowship? If yes, then apply for this research position. Two postdoctoral research positions in alternative splicing and basic diabetes are available. Universite Libre de Bruxelles (Free university of Brussels), Belgium has announced postdoctoral position in alternative splicing and basic diabetes funded by JDRF international, IMI and Welbio-FNRS, Belgium.

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The aim of this project are; 1) To study the role of alternative splicing and endoplasmic reticulum stress in β-cell dysfunction and cell death of pancreas in diabetes mellitus and 2) The generation of novel autoantigens.

Alternative splicing

Splicing is a post-transcriptional process during which recently synthesized mRNA molecules (primary RNA transcripts) are modified. During splicing, introns are spliced out from the primary RNA transcript and exons are rejoined leading to the formation of matured mRNA. There are two types of splicing; alternative splicing and constitutive splicing.

Alternative splicing is the one involved in the removal of all the introns while some exons can also be excluded leading to the formation of more than one types of final mRNA products. In this way, alternative splicing gives more than one mature mRNA products from a single primary RNA transcript and, therefore, is highly important for the study of diseases related due to defective alternative splicing.

Qualification and process of application

Suitable candidates for this position are Ph.D. graduates in biochemistry and related fields with a strong background in molecular biology and cell biology. They are also required to have strong knowledge about bioinformatics, especially in the analysis of RNA sequencing and alternative splicing.

Interested candidates can apply for this position by sending an Email to Prof. Decio L. Eizirik. Email address is deizirik@ulb.ac.be and candidates are required to send their curriculum vitae with possible publications and 2-3 recommendation letters. This vacancy was initially posted on jobs.sciencecareers.org and the last date of the application is December 11, 2015.

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