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Luxembourg Center for Systems Biomedicine, University of Luxembourg, Luxembourg, has announced a paid 6-month laboratory internship in experimental neurobiology starting from December 2015 or January 2016. The description of this project is to analyze the gene expression of the injury-response factors; Ubiquitin-specific protease-9 (USP9) and Immune-response gene-1(Irg1) in Abeta amyloid oligomer-induced Alzheimer-associated neuronal toxicity in a mouse model.
Alzheimer’s disease is one of the most common neurodegenerative diseases that affect the cognitive function early in the life with no cures up to this date. Researchers have now found out that Abeta deposits or plaques are not the primary cause of Alzheimer, but it’s the soluble Abeta moieties or oligomers that are the main cause of Alzheimer. Therefore, researchers are trying to study the neurotoxicity induced by these oligomers using a mouse model.
Selected candidates will have to measure the time-dependent expression of these injury-response factors Irg1 and USP9 in the brain of the mouse induced by the Abeta oligomers. They will also have to relate these expression data with neuropathological changes. RNA profiling and system analysis of the Abeta oligomer-induced brains and comparison of these data with human gene expression data available on the public data website are additional responsibilities of the selected candidates.
Interested candidates may apply for this post through an email address. Please send your updated curriculum vitae with possible publications and enlisted research experience in a related field to the Dr. Manuel Buttini, Luxembourg Center for Systems Biomedicine, University of Luxembourg, Luxembourg. Email id is firstname.lastname@example.org. The last date for this post is December 1, 2015. This post was originally posted in jobs.sciencecareers.org.